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____fire, all exits must be kept clear. 
A.In place ofB.Instead ofC.In case ofD.In spite of
C
in case of意为“以防万一”,根据其宾语fire可判断出“为了防止火灾,一切出口都要清除干净”。in place of 意为“代替”。instead of 意为“代替,而不是……”。in spite of 意为“不管”。
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